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KMID : 1123920090230030704
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Korean Journal of Oriental Physiology and Pathology
2009 Volume.23 No. 3 p.704 ~ p.709
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Antibacterial Activity of (2S)-7,4’-dihydroxy-5-methoxy-8-(, -dimethylally)-flavanone against Methicillin-Resistant Staphylococcus aureus
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Kim Eun-Sook
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Abstract
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The emergence of methicillin-resistant of Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) has led to an urgent need for the discovery and development of new antibacterial agents. As part of an ongoing investigation into the antibacterial properties of the natural products, (2S)-7,4’-dihydroxy-5-methoxy-8-(, -dimethylally)-f1avanone (2S-DMDF), isolated from the roots of Sophora flavescens, was found to be antibacterial active MRSA and VRE. Sophora flavescens has been used as antibacterial, antiviral, antiprotozoal, anti-inflammatory. Therefore, this study investigated the antibacterial activity of 2S-DMDF against all the bacterial strains tested. In this result, at the end point of an optically clear well, the minimum inhibitory concentrations (MICs) ranged from 0.97 to 15.6 mg/ml for 2S-DMDF, from 125 to 256 mg/ml for ampicillin, and from 64 to 512 mg/ml for gentamicin with MRSA, also, 7.8 to 15.6 mg/ml for 2S-DMDF, from 125 to 256 mg/ml for ampicillin, and from 512 to 1024< mg/ml for vacomicin with VRE. These findings indicated that the application of the tested 2S-DMDF alone might prove useful in the control and treatment of MRSA and VRE infections.
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KEYWORD
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Sophora flavescens, enterotoxin gene, (2S)-7, 4’-dihydroxy-5-methoxy-8-(, -dimethylally)-flavanone, MRSA, VRE
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